Journal of Applied Science and Engineering

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Adam Shih-Yuan Lee This email address is being protected from spambots. You need JavaScript enabled to view it.1, Ching-Hui Chung1, Yu-Ting Chang1 and Pin-Lung Chen1

1Department of Chemistry, Tamkang University, New Taipei City, Taiwan 251, R.O.C.


Received: September 23, 2011
Accepted: December 16, 2011
Publication Date: September 1, 2012

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A series of 2-arylbenzothiazoles was synthesized from the condensation reaction of aryl aldehyde with 2-aminothiophenol in the presence of L-proline under solvent-free and microwave irradiation conditions. Aromatic acids and aliphatic acids also gave the desired products in good to moderate yields under the reaction conditions. The product yields of using carboxylic acids with 2-aminothiophenol were generally lower than those of using aldehydes. This microwave-assisted L-proline catalyzed reaction provides a green and inexpensive preparation method for synthesis of 2-arylbenzothiazoles.

Keywords: 2-Arylbenzothiazole, 2-Aminothiophenol, L-Proline, Microwave Irradiation, Solvent-Free


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