Journal of Applied Science and Engineering

Published by Tamkang University Press

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Transforming Otilonium Bromide for Resilient Antimicrobial Combat

 2025

 Volume 28, Issue 10

Joanna Antos1,2, Daria Wieczorek2, Katarzyna Staszak3, Yuk-Ping Chou4, Li-Hang Hsu4, Tang-Long Shen4, and Ying-Lien Chen4

1Department of Water Supply and Bioeconomy, Faculty of Environmental Engineering and Energy, Poznan University of Technology, Berdychowo 4, 60-965 Poznan, Poland

2Department of Instrumental Technology and Analysis, Poznan University of Economics and Business, 61-875 Poznan, Poland

3Institute of Chemical Technology and Engineering, Faculty of Chemical Technology, Poznan University of Technology, ul. Berdychowo 4, 60-965 Poznan, Poland

4Department of Plant Pathology and Microbiology, National Taiwan University, Taipei, Taiwan

Received: July 29, 2024
Accepted: December 17, 2024
Publication Date: April 6, 2026

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Formation of N -substituted amidoester

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Otilonium bromide is a cationic surfactant with established medical applications, revealing a promising dimension in its versatile nature. Beyond its conventional use, the compound demonstrates notable antifungal properties, signaling a substantial extension of its application potential. Due to the spreading drug resistance of many microorganisms to active substances and antibiotics, it is necessary to search for and create new compounds that will exhibit more aggressive mechanisms of action. Based on the methods of synthesis of otilonium bromide, new derivatives of the compound were created to broaden its applicability beyond its traditional pharmaceutical utility. Delving into the intricate synthesis processes employed, this study provides a detailed exploration of the newly created derivatives of otilonium bromide. The broadening of the applicability of otilonium bromide, especially in response to emerging challenges posed by microbial resistance, is intended to make a significant contribution to the evolving landscape of antimicrobial therapeutics. The findings not only unveil the expanded capabilities of otilonium bromide but also reveal new avenues for the development of compounds with enhanced efficacy and resilience in combating microbial threats.

Keywords: otilonium bromide; cationic surfactants; drugs; antifungal properties; quaternary compounds

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